A: A piece of advice. Don't screw around with her. She's got a terrible temper.
(给你)一个忠告，别招惹她，她的脾气可坏得很。
B: She does? But she looks like a sweet little angel.
是吗？但是她看起来像个可爱善良的小天使。
Screw around with someone 这个词组基本上是从上面的“screw around”延伸出来的用法。像是对某人的态度轻慢、乱开玩笑就是这里 screw around with someone 的意思。
另外有一个跟“screw around”也有关系的词组是“screw around with something”。它的意思是“胡搞某个东西”的意思。好比有人拿着你的遥控器乱玩一番，你就可以请他“Stop screwing around with the remote control.”